Is brain prostaglandin synthesis involved in responses to cold?
نویسندگان
چکیده
منابع مشابه
Microsomal prostaglandin E synthase-1 is involved in the brain ischemic injury
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) is an inducible terminal enzyme in the synthetic pathway for PGE2, which has been demonstrated to participate in many peripheral pathological inflammatory processes. Recently, we demonstrated that mPGES-1 also has a role in brain inflammation, such as that following cerebral ischemia. The expressions of mPGES-1 and cyclooxygenase-2 (COX-2) we...
متن کاملImmune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain.
Fever occurs upon binding of prostaglandin E2 (PGE2) to EP3 receptors in the median preoptic nucleus of the hypothalamus, but the origin of the pyrogenic PGE2 has not been clearly determined. Here, using mice of both sexes, we examined the role of local versus generalized PGE2 production in the brain for the febrile response. In wild-type mice and in mice with genetic deletion of the prostaglan...
متن کاملCardiovascular responses to cold exposure.
The prevalence of hypertension is increased in winter and in cold regions of the world. Cold temperatures make hypertension worse and trigger cardiovascular complications (stroke, myocardial infarction, heart failure, etc.). Chronic or intermittent exposure to cold causes hypertension and cardiac hypertrophy in animals. The purpose of this review is to provide the recent advances in the mechani...
متن کاملInfants' brain responses to speech suggest analysis by synthesis.
Historic theories of speech perception (Motor Theory and Analysis by Synthesis) invoked listeners' knowledge of speech production to explain speech perception. Neuroimaging data show that adult listeners activate motor brain areas during speech perception. In two experiments using magnetoencephalography (MEG), we investigated motor brain activation, as well as auditory brain activation, during ...
متن کاملEnergetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections.
Hypothalamic neurons are regarded as essential for integrating thermal afferent information from skin and core and issuing commands to autonomic and behavioral effectors that maintain core temperature (T(c)) during cold exposure and for the control of energy expenditure more generally. Caudal brain stem neurons are necessary elements of the hypothalamic effector pathway and also are directly dr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1975
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1975.sp011023